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Human Rad51 filaments on double- and solitary-stranded DNA: correlating typical and irregular sorts with recombination perform.
Like a individual, I contain the biblical assignment to explore and use every little thing in generation for the good thing about my neighbour. I don't expertise any conflict involving religion and science. Quite the opposite, my faith stimulates me to complete science, to be open-minded on the earth.’
Considering that 2000, Dekker has shifted the main concentration of his perform toward biophysics where he reports the Attributes of single biomolecules and cells using the applications of nanotechnology. This transformation of subject was pushed by his fascination for the impressive operating of Organic molecular structures, along with because of the long-phrase point of view that numerous intriguing discoveries is often envisioned in this area.[5] Latest strains of investigate in his biophysics group are in the areas of:[6]
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and to start with ever study with the dynamics DNA supercoils and the discovery of supercoil hopping
Experimental section diagram of negatively supercoiled DNA calculated by magnetic tweezers and fluorescence,
We use nanofabricated microfluidic constructions to pattern spatial boundaries for microorganisms and biomimetic vesicles with reconstituted protein networks and this assess the fundamental function of spatial confinement in the molecular and cellular level. Our projects consist of the following:
He also discovered time to jot down numerous guides, deliver Just about forty thousand tweets and lead An effective research group at Delft College of Technologies. ‘It doesn’t sense like function’, he claims. ‘I’m just terribly curious.’
‘You shouldn't just think of the issues of tomorrow, but will also evaluate the thoughts of your working day just after tomorrow’
Pretty great, but that wasn’t definitely in which my fascination lay. I wanted to pioneer and I experienced the sensation that was no more probable, because the most fascinating elementary insights experienced already been uncovered. But my discipline experienced made numerous enjoyable new applications to measure personal molecules. I made a decision which i needed to apply this to biology, to take a look at it from a Bodily standpoint.’
Testing pseudotopological and nontopological styles for SMC-driven DNA loop extrusion in opposition to roadblock-traversal experiments
‘That considerations the artificial cell, as Component of the Dutch BaSyC initiative. Craig Venter looked prime-down in These times and discovered about five hundred genes that happen to be minimally needed for the functioning cell. We wish to glimpse bottom-up: how do we shift from a handful of molecules to an entire Organic method?
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of an individual wire bridging two electrodes
The biophysicist from Delft – who is Just about the most cited scientists within the Netherlands for years – takes his obligation to add on the clarification and popularisation of his perform in the border of ceesdekker.net physics and biology extremely seriously and consistently seems inside the media; if not to take a look at his get the job done, then about the relationship between science and his Christian religion.